Based on a combination of the patient’s clinical symptoms and auxiliary examinations, including low positivity for IgG anticardiolipin antibody (aCL) and lupus anticoagulant (LA), and high-titer IgA anti-β2GPI (Table 2), we were able to finally diagnose the patient with CAPS, COVID-19 (moderate), multiple vascular embolism, and multiple organ dysfunction. The gene discussed is APOH; the disease is COVID-19.