Coagulation disorders and thrombosis, characterized by arterial, venous, and microvascular thromboses, occur frequently in patients with COVID-19.[1] Antiphospholipid antibodies (aPL), which are conventionally positive in antiphospholipid syndrome (APS) and its severe form, catastrophic antiphospholipid syndrome (CAPS), are consistently reported in these patients.[2] The occurrence of multiple thrombi and multi-organ failure in CAPS and COVID-19 may share common pathogenic mechanisms. The gene discussed is FASLG; the disease is deep vein thrombosis.