NF1 and melanoma: Neurofibrin is a negative regulator of neural crista-derived tissue growth and differentiation, and thus, patients with NF1 are at increased risk of developing neural crista-derived tumors.[10] However, although melanocytes originate from the neural crest and NF1 is frequently mutated in sporadic melanomas,[11] and previous case reports have suggested the presence of a relationship between melanoma and NF1, this has not been confirmed by large population-based studies.