By analyzing the yearly frequency of SMA-related keyword usage in relevant international publications, we found increasing trends for the following keywords: SMA, nusinersen, ALS, SMN1, gene therapy, motor neuron disease, SMN2, neuromuscular disease, Duchenne muscular dystrophy, and neurodegeneration (Fig. 5A). This evidence concerns the gene SMN2 and proximal spinal muscular atrophy.