RHOA and hypertensive disorder: At the same time, RAS also contributes to anxiety onset,[101] and its mechanism of action may be induction of neuroinflammation and oxidative stress.[99] Elevated levels of IL-6[102] and IL-17 have been observed in patients with anxiety disorders.[103,104] IL-6 receptors are involved in and promote thrombosis, stimulate chronic inflammation,[102] promote Na + reabsorption[105] and activation of the RAS system,[106] leading to hypertension; IL-17 promotes inflammation[107] and activates RhoA/Rho-kinase,[108] leading to endothelial dysfunction and hypertension.