Wei Cheng and colleagues confirmed that GDF1 can inhibit the excessive proliferation of hepatocellular carcinoma, but can promote its metastasis through activating the activin receptor-like kinase 7 (ALK7).[44] One research found that the epigenetic silencing of GDF1 leads to the occurrence of GC.[45] While our report verified that high GDF1 expression was significantly correlated with poor OS and DFS that it can be considered as prognostic biomarkers for GC. This evidence concerns the gene ACVR1C and gastric cancer.