GDF7, a member of the GDFs family of TGF-β, is abundant in multiple cancers including endometrial cancer,[54] medulloblastoma,[55] and Barrett esophagus.[56] In this present study, GDF7 was significantly down regulated in GC while a higher GDF7 expression was correlated with significant poorer OS and DFS in patients with GC. The gene discussed is GDF7; the disease is esophageal adenocarcinoma.