TP53 and neoplasm: Researchers found that alanyl-tRNA synthetase 1 (AARS1) can bind to lactate, catalyze the formation of lactate-adenosine monophosphate (lactate-AMP), and then transfer lactate to lysine 120 and lysine 139 in the DNA binding domain of p53, which hinders its liquid-liquid separation and transcriptional activation, and promotes tumor progression.