EPB41L4A-AS1, a long non-coding RNA (lncRNA) downregulated during aging and in AD, regulate histone acetyltransferase 5-like 2 (GCN5L2) expression to enhance histone acetylation, crotonylation and lactylation near the transcription site of autophagy-related genes, further enhancing astrocyte-mediated clearance of amyloid β peptide (Aβ) and delaying the progression of AD [130]. The gene discussed is EPB41L4A; the disease is Alzheimer disease.