It is noteworthy that another estrogen binding receptor, the G protein-coupled estrogen receptor, plays an essential role in colorectal carcinogenesis by elevating the expression and activity of several oncogenes such as FASN in the colon through EGFR/ERK/c-Fos/AP-1 signaling, which subsequently results in increased CRC cell growth, invasion, and migration [87, 88]. Here, FOS is linked to colorectal carcinoma.