CLOCK and cancer: In GSE199057 on females only (Supplementary Tables 9-11 and Supplementary Fig. 8-10), similar to the findings from TCGA females, Levine’s clock was positively associated with CRC tissues, compared with adjacent normal tissues, while both Horvath’s and Hannum’s clocks were negatively correlated with CRC tissues, compared with adjacent normal tissues and normal tissues from women who remained cancer free, respectively.