In a CLP model of sepsis induction, electron microscopy revealed a reduction in autophagic vesicles within the spleens of T-cell-specific Atg7-deficient mice post-CLP, which presented increased mortality rates due to sepsis, increased T-cell apoptosis, and depletion of CD4+ and CD8+ T cells [189]. The gene discussed is CD8A; the disease is Sepsis.