Although the exact etiology of Alzheimer's Disease is not yet fully understood, research indicates that its pathogenesis is associated with multiple factors, among which the most critical include the deposition of β-amyloid protein (Aβ) [6,7], abnormal phosphorylation of Tau protein [8], neurodegenerative lesions [9], and disruption of the blood-brain barrier [10]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.