These pathological features can trigger neuroinflammation [11, 12], and increasing evidence suggests that various cytokines, including IL-6, IL-1β, TNF-α, TGF-β, and IFN-γ, actively participate in AD pathogenesis and may serve as diagnostic or therapeutic targets for AD neurodegeneration [12-14]. The gene discussed is TGFB1; the disease is Alzheimer disease.