We do not have access to phenotypic data in these control datasets to ascertain whether the LOF carriers have IgAN or related phenotypes, such has microhematuria and IgAV, but the approximate 5-fold–higher frequency of LOF variants among IgAN cases, together with the cosegregation with disease in the original family, indicate GALNT14-LOF variants may be a risk factor for disease. This evidence concerns the gene GALNT14 and Microscopic hematuria.