However, recent research has challenged this notion, shedding light on inspiratory flow limitation and hypoglossal nerve function in mice [21,22], and on the spontaneous occurrence of OSA-like events not only in a mouse model of Down syndrome (Ts65Dn mice) and of CDKL5 deficiency disorder (CDKL5 knock-out mice), but also in wild-type mice [23–25]. Here, CDKL5 is linked to Down syndrome.