Similarly, it has been found that in primary hepatocellular carcinoma cells, the maturation of miR-126 is mediated by the methylation transferase METTL14, and a decrease in the expression of mature miR-126 can cause the transfer of primary hepatocellular carcinoma cells [42]; when METTL3 is knocked down, the expression of mature miRNA is reduced due to the impact on m6A modification on pri-miRNA, further confirming the regulation of pri-miRNA processing by m6A modification. This evidence concerns the gene METTL3 and hepatocellular carcinoma.