These data indicate that the aberrant epigenetic pathways contributing to Pcyt2 + /- NASH were reversed by PEA treatment, likely in part through the restoration of methylation status of key DNA/histone methylation enzymes and hypermethylation of histone methyltransferases Prdm9, Ash1l. Here, PRDM9 is linked to metabolic dysfunction-associated steatohepatitis.