Because PEA was not able to completely reverse Pcyt2 + /- NASH [16] and influences processes beyond the CDP-ethanolamine pathway [75,76], the subset of genes that exhibited elevated hyper-/hypomethylation of DMGs in response to PEA were examined as they may suggest pathways that affect NASH amelioration. Here, PCYT2 is linked to metabolic dysfunction-associated steatohepatitis.