The heatmap (Fig. 3C, Table S4) identified DMEGs in several NASH modulated genes from the insulin/glucose metabolism (Irs2, Ptprf, Hk2, Sorbs1), fatty acid metabolism (Slc27a4, Acaca), MAPK signalling (Kras, Map2k1, Rps6ka1), JAK/STAT signalling (Stat3, Stat5a, Sh2b2, Csf1r, Egfr), inflammation (Ifngr1, Il10ra, Nfkb1), cell growth (Igf1r, Pparg, Smad5, Gab), and apoptosis (Bcl2l1). This evidence concerns the gene IRS2 and metabolic dysfunction-associated steatohepatitis.