Specifically, mitochondrial regulators and fatty acid metabolism proteins are defective in young mice and persist into adulthood, and here, we show that genes involved in these pathways including mitochondrial function (Ndufv2, Pink1, Mtch2), lipid metabolism (Pnpla2, Pitpnc1), glucose homeostasis (Foxo1) exhibit the most drastic changes in methylation and expression, and exert the greatest connectively within the protein interaction network indicating these as important epigenetically regulated genes in Pcyt2 + /- NASH. Here, PINK1 is linked to metabolic dysfunction-associated steatohepatitis.