The same cell cycle genes (Cdk14, Cdk17 and Anapc5) show aberrant methylation and expression in both young and adult Pcyt2 + /-, and the alternative NASH model (methionine/choline-deficient/high fat diet), indicating their strong relevance to NASH development and as potential prognostic indicators. The gene discussed is ANAPC5; the disease is metabolic dysfunction-associated steatohepatitis.