The overall effect size for TLR4 gene expression (0.179, 95% CI: –0.502 to 0.861) revealed a nonsignificant increase in TLR4 expression in patients with schizophrenia, with no significant difference between the subgroups (Qb (1) = 0.53, p = 0.467) (Fig 2-C). Here, TLR4 is linked to schizophrenia.