HP and colorectal carcinoma: In order to elucidate this aspect, we performed further analyses by adding terms for zonulin and 16S rRNA gene copies in our core model, and found that the OR of CRC for aspirin use was lower (OR = 0.18, 95% CI = 0.05-0.67) as compared to the one obtained from the core model (OR = 0.43, 95% CI = 0.19-0.96).