Several others, 8-OHdG, Ca2+, IL-6, IL-8, resistin, TNF-α, and AEA, have been identified as predictors, as they have previously been associated with an increased risk of developing obesity-related conditions such as insulin resistance, metabolic syndrome, or cardiovascular disease. Here, CXCL8 is linked to obesity due to melanocortin 4 receptor deficiency.