Although biomarkers such as 8-OHdG, IL-8, resistin, TNFR1, PTX-3, and sICAM-1 are closely associated with MUO and metabolic disorders, they have not yet been established as primary diagnostic biomarkers for obesity-tests in clinical practice. The gene discussed is CXCL8; the disease is obesity due to melanocortin 4 receptor deficiency.