However, in contrast to pulmonary SCNEC, data regarding DLL3 expression in extrapulmonary SCNEC, pulmonary and extrapulmonary large cell NEC (LCNEC), mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN), gastroenteropancreatic NET (GEP-NET), and pulmonary carcinoids is scarce [8, 18]. The gene discussed is DLL3; the disease is large cell neuroendocrine carcinoma.