DLL3 and neuroendocrine carcinoma: In the overall cohort, general DLL3 expression (any degree) was far more frequent in NEC (201/314; 64.0%; p < 0.001) than in NET and pulmonary carcinoids (99/980; 10.1%), also with much higher frequencies of moderate and strongly positive NEC (NEC: 176/314, 56.1%; NET/TC/AC: 62/980, 6.3%; p < 0.001) (Fig. 1E).