ADCC activity and titer were measured using plasma samples from weeks 5, 12, and 21 post-infection (Fig. 4B through I) in three groups of animals: (1) CD8+, NK cell, and monocyte triple depleted (TD) animals infected with HTLV-1A wild type (WT) virus (TD-WT, shown in black, n = 5); (2) CD8+, NK cell, and monocyte triple depleted animals infected with chimeric HTLV-1A/C virus (TD-ACO1-L, shown in red, n = 4); and (3) non-depleted (ND) animals infected with chimeric HTLV-1A/C virus (ND-ACO1-L, shown in blue, n = 4). The gene discussed is CD8A; the disease is infection.