The two mRNA-encoding genes in this subset have been associated with SCC: PTHLH has been recognized as a promoter of tumour growth in HNSC and AIM2 as a regulator of both growth and invasiveness of cSCC.50,51 These observations suggest that the three consistently differentially expressed lncRNA transcripts, AC108142.1, RP11-554I8.2 and RP13-463N16.6 – which remain functionally uncharacterized – may play direct tumorigenic roles in cSCC. Here, AIM2 is linked to skin squamous cell carcinoma.