Similar to the result in MM, patients at Mayo stages I and II of the MGA-SYNE1-mut subgroup exhibited early deterioration (P = 0.029), whereas those of the ZFHX3-DIS3-mut subgroup were free from disease progression until approximately the 40th month (Figure 5C, Figure S3D). This evidence concerns the gene ZFHX3 and Miyoshi myopathy.