In MM, myeloma driver genes such as KRAS, NRAS, BRAF, MYC, and FGFR3 were mainly subclonal, whereas myeloid CH mutations, such as those in TP53, CREBBP, EP300, TET2, and JAK2, and lymphoid CH mutations, such as those in MGA, SYNE1, FAT1, KMT2D, and HIST1H1D1, appeared in dominant clonal BMPCs (Figure 1C; Table S2). This evidence concerns the gene EP300 and plasma cell myeloma.