The observation of malfunctioning leaky RyR2 channels in SARS‐CoV‐2 infected individuals, in conjunction with the established role of neuronal RyR2 remodeling in cognitive dysfunction induced by physiological stress [54], strongly suggested the potential contribution of dysregulated RyR2 signaling in the symptoms of cognitive impairment following SARS‐CoV‐2 infection (Figure 4). Here, RYR2 is linked to Cognitive impairment.