Intracellular expression of MAGE-A4 has been observed in several tumor types (5, 6), with ≥20% prevalence reported in synovial sarcoma and myxoid/round cell liposarcoma, bladder urothelial carcinoma, gastric cancer, ovarian carcinoma, esophageal cancer, and head and neck squamous cell carcinoma (HNSCC) (6). This evidence concerns the gene MAGEA4 and head and neck squamous cell carcinoma.