Tumor invasion and metastasis are complex biological processes involving several oncogenes and tumor suppressor genes that regulate tumor growth and metastasis and several signaling pathways including Notch, JNK, Raf-MAPK, WNT, and Hippo (Lin et al., 2019; Zhang et al., 2019; Yang et al., 2022). This evidence concerns the gene MAPK8 and neoplasm.