The eyeful tumor invasion model was established by crossing corresponding transgenic fly strains using a robust GAL4/UAS dual expression system (Brand and Perrimon, 1993; Ferres-Marco et al., 2006; Zhang et al., 2019) to ectopically express Delta (a Notch pathway ligand) and downregulate the epigenetic silencing factors pipsqueak (psq) and longitudinals lacking (lola). The gene discussed is LGALS4; the disease is neoplasm.