Several circulating autoantibodies like apL antibodies and β2-glycoprotein antibodies correlate with disease activities, specifically focal events such as cerebrovascular disease and seizures. Antiribosomal P antibodies were found to be specifically related to lupus psychosis. Aquaporin 4 autoantibodies can help diagnose a patient with myelopathy, optic neuritis, and NMO. This evidence concerns the gene OCA2 and neuromyelitis optica.