A comprehensive assessment has been conducted on the collective impact of SNPs in multiple genes linked to SLE, namely HLADRB1, IRF5, STAT4, BLK, TNFAIP3, TNIP1, FCGR2B, and TNFSF13, in Japanese individuals diagnosed with SLE. The gene discussed is FCGR2B; the disease is systemic lupus erythematosus.