TGFB1 and neoplasm: Anti-TIF1γ-positive dermatomyositis is a unique subtype marked by the presence of antibodies against TIF1γ in the serum, a 155-kDa nuclear protein that acts as a tumor suppressor gene and is implicated in multiple mechanisms of DNA transcription and repair through the regulation of the Smad/transforming growth factor-beta (TGF-β) and Wnt/β-catenin pathways [2-4].