LTF, liver transplantation free; FDA, Food and Drug Administration; PPAR, peroxisome proliferator-activated receptors; ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; HCC, hepatocellular carcinoma; FGF, fibroblast growth factor; ASBT, apical sodium-dependent bile acid transporter; TGR, Takeda G protein-coupled receptor 5; PDC-E2, pyruvate dehydrogenase complex E2 component. The gene discussed is SLC10A2; the disease is hepatocellular carcinoma.