AR and sarcopenia: In conclusion, this is the study showing that increased DNA methylation in skeletal muscle disrupts muscle homeostasis and leads to (1) increased inflammatory and senescent signatures in skeletal muscle, (2) shift to slow myofibers (occurs in sarcopenia), (3) decreased AR signaling, (4) decreased mitochondrial OXPHOS complex I protein level, (5) low basal autophagy, and (6) fast myofiber-specific muscle atrophy.