REG3G is essential for separation between microbiota and intestinal epithelial cells.23, 49 Alcohol downregulates REG3G expression in duodenal biopsies from patients with alcohol use disorder as well as Reg3b and Reg3g expression in mice.9,12,14 Decreased Reg3g levels promote attachment of bacteria to epithelial cells and enhance bacterial translocation, which causes an inflammatory response in the liver and worsens ethanol-induced liver disease in mice.14 Overexpression of Reg3g in intestinal epithelial cells shows the opposite effect. The gene discussed is REG3G; the disease is alcohol abuse.