DNMT3A and acute myeloid leukemia: To determine whether T cell clone 1.5.F1DNMT3A was able to kill AML cells with DNMT3A-R882H, clone 1.5.F1DNMT3A was coincubated with patient-derived AML samples (n=4) for 48 hours, and numbers of viable HLA-DQ-expressing AML cells were measured in a flow cytometry-based killing assay (Figure 7C and Supplementary Figure 6).