AIT, allergen immunotherapy; SCORAD, scoring atopic dermatitis index; POEM, patient-oriented eczema measure; Itch-NRS, itch numerical rating scale; ADCT, atopic dermatitis control test; DLQI, dermatology life quality index; tIgE, total IgE; sIgE, specific IgE; Der p, Dermatophagoides pteronyssinus; Der f, Dermatophagoides farina. The gene discussed is IGHE; the disease is atopic eczema.