Hypertension, proportion of CAF, homocysteine, NLR, D-dimer, uric acid, PTFV1 < −0.03 mm s, gal-3, and TGF-β1, were risk factors for the development of high CBS in atrial fibrillation (AF), and hypertension and CAF were the most important factors for the occurrence of AF in the independent risk factors for stroke combined with high clot burden. Here, LGALS3 is linked to atrial fibrillation.