The proportion of hypertensive patients and CAF patients, BNP, NLR, UA, D-dimer, concentration, percentage of PTFV1 < −0.03 mm s, gal-3, and TGF-β1 were higher in the CBS (score of 0–6) group, and hypertension and CAF were independent risk factors for high clot burden. Here, LGALS3 is linked to Hypertension.