Indeed, some research groups have made a negative comment on the active role of CD169‐positive macrophages in cancer immunity: (1) when CD169‐positive macrophages are associated with tumors, the macrophages promote metastasis (Gunnarsdottir et al., 2023); and (2) SCS CD169‐positive macrophages in lymph nodes provide anchorage of metastatic melanoma cells (Singh & Choi, 2019). This evidence concerns the gene SIGLEC1 and cancer.