Immunohistochemical and morphometric analyses were performed to examine DC‐SIGN‐, CD68‐, and CD169‐positive cells in the subcarinal node (proximal) and paratracheal nodes (distal nodes) from 16 patients with lower‐lobe lung cancer without metastasis (adenocarcinoma, 11; squamous, 5). This evidence concerns the gene SIGLEC1 and adenocarcinoma.