Incorporation of MSCs, monocytes, and CRC cells in a gelatine/methacryloyl‐based hydrogel demonstrated enhanced expression of matrix remodeling proteins FN1 and MMP9, induced release of tumor‐promoting immune molecules MIF, Serpin E1, CXCL1, IL‐8, and CXCL12 by MSCs, leading to the suppression of the anti‐tumor functions in macrophages [66]. This evidence concerns the gene SERPINE1 and neoplasm.