Co‐culture of MDA‐MB‐231 breast cancer cells with monocytes and endothelial cells in the presence of interstitial fluid flow significantly enhances the activation of monocytes to tumor‐associated macrophages (TAM)‐like phenotype through stimulation by colony‐stimulating factor 1 (CSF‐1) [44]. The gene discussed is CSF1; the disease is neoplasm.