Consistent with previous reports using this NGF isocaloric paradigm,[42] after 6–7 weeks feeding, despite similar fat mass, mice fed on HF were the leanest while the HP were the heaviest (Figure S2A, Supporting Information), coinciding with highest fasting blood glucose and insulin and their products (similar to homeostatic model‐assessment of insulin resistance, HOMA‐IR, in human) in HP (Figure S2B–D, Supporting Information). Here, INS is linked to hydrops fetalis.