Carnitine palmitoyltransferase 1A (CPT1A) is involved in fatty acid oxidation, associated both with immune activation[32, 33] and tolerance.[63] Higher CPT1A levels in T cells and cDCs were found in HC group with more severe symptoms (Figure 3F), consistent with enhanced fatty acid metabolism during EAE/MS revealed by scRNA‐seq. This evidence concerns the gene CPT1A and myeloid sarcoma.