CD274 and neoplasm: Figure 4A illustrates that immunity-H has higher anti-tumor TME components like activated memory CD4+ T cells, macrophages M1 cells, and dendritic cells. The correlation analysis revealed a relationship between weak CD4+ T and mast cells and mRNAsi abundance (Figure 4C). We further observed elevated expressions of several immune checkpoints in the high immune infiltration group, such as CD86, CD274, CD80, CD276, CTLA4, PDCD1, and PDCD1LG2. However, this trend was reversed in the high mRNAsi group (Figure 4B–D).