Moreover, Zhao et al. [43] underscored the role of metabolic disturbances in midpalatal suture remodelling during rapid maxillary expansion (RME), suggesting that obesity-associated FTO protein enhances osteogenic differentiation in suture mesenchymal stem cells, potentially influencing maxillary expansion outcomes. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.