C-reactive protein ≥ 3 mg/dL and erythrocyte sedimentation rate ≥40 mm/h, if associated with three or more abnormal laboratory findings, such as anemia for the age of the child, platelets ≥ 450,000/μL after the seventh day of fever, albumin ≤ 3 gr/dL, increased alanine aminotransferase, white blood cell count ≥ 15,000/mm3, ≥10 white blood cells/high-power field in the urine, and an abnormal echocardiogram identify the candidates for treatment [11]. This evidence concerns the gene CRP and anemia.