Moreover, after extensive ileum resection, GLP-1 receptor agonists allow restoration of the negative feedback mechanisms and a reduction in diarrhea due to prolonged SB transit time, inhibiting hepatic bile acids production and upper gastrointestinal secretions, all related to intestinal dysbiosis and metabolic complications in SBS. The gene discussed is GLP1R; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.