SHOX and Turner syndrome: No manuscript compared the different efficacy between pubertal and prepubertal patients, while one paper performed a comparison between patients with SHOX gene mutations and patients with Turner syndrome [42], showing a similar height benefit between the two conditions; these data are consistent with the genetic pathogenesis of Turner syndrome, as the short stature in this syndrome is caused by the reduced expression of the SHOX gene due to the absence of one X chromosome [44].