In addition, epigenetic changes, such as polymorphisms in the MKRN3 and LIN28B genes, as well as prenatal and postnatal environmental factors, intestinal microbiota, and endocrine disruptors, are also associated with the adolescent development of children and adolescents with obesity [20]. This evidence concerns the gene MKRN3 and obesity due to melanocortin 4 receptor deficiency.