Windham et al. [50] examined the impact of smoking on the hormonal function of women of childbearing age by measuring the levels of the pituitary hormone follicle-stimulating hormone (FSH) in 403 women and found that urinary FSH levels were approximately 30–35% higher in smokers than in non-smokers, suggesting that the chemicals in tobacco could affect endocrine regulation and the secretion of pituitary hormones, and potentially causing menstrual disorders. The gene discussed is BRD2; the disease is Menstrual disorder.