It has been shown that dandelion root and leaf extract has the potential to prevent and relieve obesity-associated NAFLD by significantly reducing hepatic lipid accumulation in mice and can reduce HFD-induced TG, TC, insulin, serum fasting blood glucose levels through activation of the adenosine monophosphate-activated protein kinase (AMPK) pathway [43]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.