Certain neurohormonal and metabolic derangements in obesity, such as increased sympathetic tone, RAAS activation, hyperinsulinemia, hyperleptinemia, and reduced adiponectin, may contribute to LV hypertrophy and better prognosis (Badano et al., 2004; Bursi et al., 2006). The gene discussed is ADIPOQ; the disease is hyperinsulinism.