Cancer cells can activate the coagulation cascade through tissue factor (TF) expression and inflammatory cytokines (TNF-α and IL-1β), consequently stimulating vascular cells, monocytes, and macrophages to express TF, which in turn induces the conversion of factor VII to factor VIIa, thus activating the extrinsic pathway of the coagulation cascade [22,23]. This evidence concerns the gene TF and cancer.