Finally, in comparison to HC, in DM patients with encephalopathy, we evidenced a higher proportion of CD57+ CD4+ T cells (CD57+ CD4+ 17.1% [7.23–19.1] vs. 1.01% [0.70–2.03] p = 0.029), increased absolute number and proportion of CD73+ CD8+ T cells (CD73+ CD8+ 139 cells/μL [72.5–764] vs. 4.26 cells/μL [1–8.56] p = 0.048), and (14.8% [12.3–86.9] vs. 2.26% [0.82–3.21] p = 0.039) respectively (Figure 5f,g). The gene discussed is NT5E; the disease is Encephalopathy.