The vasculopathy involved in dermatomyositis is promoted by priming endothelial cells, which could activate mainly T effector memory cells, especially CD45RA−CCR7−CD27− through CD69 stable expression, suggesting this pathway as one of the first events priming of transmigrating T cells to requirements of tissue-residency such as muscle, skin, or CNS vessels [36]. The gene discussed is CD69; the disease is dermatomyositis.