Multivariable Cox regression analysis confirmed ComBx as a significant predictor for BCR after PCa treatments (RP or RT) (HR:0.37 (95%CI 0.20–0.70); p = 0.002) even after controlling for race, DRE findings, family history of PCa, biopsy results, PSA value, and age (Table 3). This evidence concerns the gene KLK3 and posterior cortical atrophy.