Combined elevated levels of scabies-specific IgE and IgG4 in the plasma of individuals with crusted scabies, along with the documented clinical eosinophilia in these patients, collectively suggest an increased production of the cytokines IL-4, IL-5, and IL-13 in combination with a non-protective Th2 response [44]. The gene discussed is IGHE; the disease is Increased total eosinophil count.