MFS is a complex systemic disorder characterized by significant inter- and intrafamilial variability primarily affecting connective tissues; this variability is due to heterozygous mutations in the fibrillin-1 (FBN1) gene, located on the long arm of chromosome 15 (15q21.1), which encodes the extracellular matrix protein [2]. This evidence concerns the gene FBN1 and Marfan syndrome.