The occurrence of the chromosomal translocation (1;19)(q23; p13.3)/TCF3(E2A)-PBX1 is observed in a small percentage of adult ALL cases and a slightly larger percentage of pediatric ALL cases [36]; in this cohort, we observed eight patients with this translocation and one patient was MRD-positive and relapsed. This evidence concerns the gene PBX1 and acute lymphoblastic leukemia.