Downregulation of TNIP1 has been experimentally linked to increased severity of phenotypic psoriasis [21], while introduction of a ubiquitin-binding attenuating aspartate-to-asparagine (D–N) variant of the TNIP1 protein into mice (D485N in mouse sequence, D472N in human sequence) results in an SLE-like disease state [22,23]. The gene discussed is TNIP1; the disease is psoriasis.